INFUSION AND SUPPLEMENTATION

1.  IV Infusion of NAD⁺ or its Precursors

Intravenous (IV) infusion delivers NAD⁺ or its precursors directly into the bloodstream, bypassing the digestive system. This allows for:

  • Immediate bioavailability
  • Higher plasma concentrations than oral intake
  • Use in clinical or wellness settings, often for fatigue, cognitive support, or recovery from substance use

However, IV therapy is invasive, may cause side effects (e.g. nausea, flushing if administered too fast), and is not yet supported by strong clinical evidence in healthy individuals.

 

2. Oral Supplements (NAD⁺ Precursors)

These are widely available as capsules or powders and include:

  • Nicotinamide Riboside (NR)
  • Nicotinamide Mononucleotide (NMN)
  • Nicotinamide (NAM)
  • Nicotinic Acid (Niacin)

They are precursors that the body can convert into NAD⁺. Research suggests that NR and NMN are the most effective at raising NAD⁺ levels in cells. They are generally well tolerated and have become popular in the anti-aging and wellness community.

 

3. NAD⁺-Supporting Natural Foods

Certain foods are rich in vitamin B3 (niacin and its forms), which the body uses to create NAD⁺. These include:

  • Meat and fish (e.g. chicken, turkey, salmon)
  • Whole grains and brown rice
  • Legumes (e.g. lentils, peanuts)
  • Dairy (e.g. milk)
  • Mushrooms and green vegetables (e.g. broccoli, spinach)

While food alone may not dramatically boost NAD⁺ in aging individuals, a balanced diet helps maintain healthy baseline levels and supports overall metabolic function.